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APC KAPS-Paper-1 Exam Syllabus Topics:

SectionWeightObjectives
Pharmaceutical Chemistry30%- Analytical Chemistry
  • 1. Quality control and purity assessment
    • 2. Principles of drug analysis and identification
      - Physical Pharmacy
      • 1. Chemical kinetics and shelf-life
        • 2. Solubility and dissolution
          • 3. Partition coefficient and pH-partition theory
            • 4. Physicochemical properties affecting drug action
              - Medicinal and Organic Chemistry
              • 1. Drug classification and nomenclature
                • 2. Acid-base properties and pKa
                  • 3. Drug stability and degradation pathways
                    • 4. Functional groups and chemical reactivity
                      • 5. Stereochemistry and isomerism
                        Physiology and Pharmacology70%- General Pharmacology
                        • 1. Drug interactions and adverse effects
                          • 2. Pharmacokinetics: absorption, distribution, metabolism, excretion
                            • 3. Drug-protein binding and clearance
                              • 4. Mechanisms of drug action and receptor theory
                                - Systemic Pharmacology
                                • 1. Respiratory and gastrointestinal drugs
                                  • 2. Cardiovascular and renal pharmacology
                                    • 3. Central nervous system drugs
                                      • 4. Autonomic nervous system drugs
                                        • 5. Endocrine and metabolic pharmacology
                                          • 6. Anti-inflammatory, analgesic and immunomodulatory drugs
                                            - Chemotherapy
                                            • 1. Antiparasitic and antineoplastic drugs
                                              • 2. Principles of antimicrobial resistance
                                                • 3. Antibacterial, antiviral and antifungal agents

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