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ACRP ACRP-CP Exam Syllabus Topics:

SectionWeightObjectives
Topic 1: Study Design and Conduct17%- Study implementation
  • 1. Study monitoring and oversight
  • 2. Investigational product management
  • 3. Site selection and activation
- Study planning
  • 1. Protocol development and amendments
  • 2. Sample size and statistical considerations
  • 3. Study population and eligibility criteria
Topic 2: Professionalism and Ethical Practice15%- Continuous improvement
  • 1. Quality assurance and process improvement
  • 2. Professional development and education
- Professional standards
  • 1. Confidentiality and conflict of interest
  • 2. Role responsibilities and boundaries
Topic 3: Clinical Study Operations15%- Site management
  • 1. Study documentation and record keeping
  • 2. Site personnel training and delegation
- Project management
  • 1. Vendor and stakeholder management
  • 2. Timeline and budget management
Topic 4: Ethical and Participant Safety Considerations19%- Clinical care and management of research participants
  • 1. Standard of care vs protocol requirements
  • 2. Informed consent development and review
  • 3. Continuity of medical care
- Ethical principles
  • 1. Clinical equipoise and therapeutic misconception
  • 2. Human subject protections and privacy
- Safety monitoring and reporting
  • 1. Adverse event identification and classification
  • 2. Safety information evaluation and communication
Topic 5: Regulatory and Compliance Requirements17%- International standards
  • 1. Declaration of Helsinki
- Compliance procedures
  • 1. Audits and inspections
  • 2. Regulatory submissions and approvals
- ICH Guidelines
  • 1. E9 Statistical Principles
  • 2. E8 General Considerations for Clinical Trials
  • 3. E2A Expedited Reporting
  • 4. E11 Pediatric Trials
  • 5. E6(R2)/E6(R3) Good Clinical Practice
Topic 6: Data Management and Informatics17%- Data reporting
  • 1. Database lock and data transfer
  • 2. Data integrity and security
- Data quality control
  • 1. Data validation and cleaning
  • 2. Query management and resolution
- Data collection
  • 1. Electronic data capture systems
  • 2. Case report form design and completion

ACRP Certified Professional Sample Questions:

A trial subject was involved in a traffic accident. The emergency room (ER) doctor notifies the investigator that he wants to give the subject a blood transfusion. Blood transfusion is one of the prohibited treatments in the trial. How should the investigator respond?

  • A. Ask the ER doctor not to transfuse blood and consider another treatment compliant with the protocol.
  • B. Advise the ER doctor to transfuse blood, and the PI should withdraw the subject from the trial.
  • C. Advise the ER doctor to transfuse the blood, and the PI should report this incident to the sponsor.
  • D. Report this incident immediately to the sponsor and leave the treatment decision to them.
Reveal Solution  Discussion  0

Correct Answer: C  🗳️

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A deferred consent can take place in which of the following situations?

  • A. In an emergency situation only, when this process is described in the protocol and has received permission from the ethics committee.
  • B. In an emergency situation only, even when this process is not described in the protocol, but the sponsor approves the consent process.
  • C. Only when the PI approves such a consent process immediately prior to patient enrollment, regardless of the situation being classed as emergency.
  • D. Only when the PI approves such a consent process, regardless of the emergency situation described in the protocol.
Reveal Solution  Discussion  0

Correct Answer: A  🗳️

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The CRC is prepared to consent a cognitively impaired participant to an Alzheimer's clinical trial. The CRC is required to utilize which of the following in the consent process?

  • A. A legally acceptable representative
  • B. A family member
  • C. A witness
  • D. A member of the research team
Reveal Solution  Discussion  0

Correct Answer: A  🗳️

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In order to conduct open-label, parallel group clinical trials according to sound scientific principles, which of the following design elements should be included?

  • A. Randomization
  • B. Privacy controls
  • C. Blinding
  • D. Placebo-controlled
Reveal Solution  Discussion  0

Correct Answer: A  🗳️

Explanation: Only visible for TestKingFree members. You can sign-up / login (it's free).

Confidentiality and privacy rules for protection of human subjects at research sites are determined by the:

  • A. Applicable regulatory authorities
  • B. Applicable site SOPs
  • C. Sponsor
  • D. PI
Reveal Solution  Discussion  0

Correct Answer: A  🗳️

Explanation: Only visible for TestKingFree members. You can sign-up / login (it's free).

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